{"id":1746,"date":"2024-05-11T18:32:10","date_gmt":"2024-05-11T10:32:10","guid":{"rendered":"http:\/\/www.commedx.com\/en\/?page_id=1746"},"modified":"2024-05-19T13:05:26","modified_gmt":"2024-05-19T05:05:26","slug":"virtual-screening","status":"publish","type":"page","link":"http:\/\/www.commedx.com\/en\/services\/virtual-screening\/","title":{"rendered":"Virtual screening"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1746\" class=\"elementor elementor-1746\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-12ef67f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"12ef67f\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c14c27c\" data-id=\"c14c27c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-69325b7 elementor-widget elementor-widget-spacer\" data-id=\"69325b7\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-15a254bf elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"15a254bf\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2313ca6a\" data-id=\"2313ca6a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-197849c elementor-widget elementor-widget-heading\" data-id=\"197849c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Drug Development Services<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2c13069a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2c13069a\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-custom\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-21fc1b35\" data-id=\"21fc1b35\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-47e02891 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"47e02891\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-6f860a86\" data-id=\"6f860a86\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2de41f7b elementor-widget elementor-widget-template\" data-id=\"2de41f7b\" data-element_type=\"widget\" data-widget_type=\"template.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-template\">\n\t\t\t\t\t<div data-elementor-type=\"section\" data-elementor-id=\"1764\" class=\"elementor elementor-1764\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-45bfdc57 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"45bfdc57\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-4a6768e0\" data-id=\"4a6768e0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d1de814 elementor-widget elementor-widget-nav-menu\" data-id=\"d1de814\" data-element_type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;dropdown&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;i class=\\&quot;fas fa-chevron-down\\&quot;&gt;&lt;\\\/i&gt;&quot;,&quot;library&quot;:&quot;fa-solid&quot;}}\" data-widget_type=\"nav-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-d1de814\" class=\"elementor-nav-menu\"><li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-1871\"><a class=\"elementor-item menu-link\" tabindex=\"-1\">Computational chemistry<\/a>\n<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1884\"><a href=\"http:\/\/www.commedx.com\/en\/services\/virtual-screening\/\" class=\"elementor-sub-item menu-link\" tabindex=\"-1\">Virtual screening<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1879\"><a href=\"http:\/\/www.commedx.com\/en\/services\/ligand-binding-mode-prediction\/\" class=\"elementor-sub-item menu-link\" tabindex=\"-1\">Ligand binding mode prediction<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1880\"><a href=\"http:\/\/www.commedx.com\/en\/services\/molecular-dynamics-simulations\/\" class=\"elementor-sub-item menu-link\" tabindex=\"-1\">Molecular dynamics simulations<\/a><\/li>\n\t<li 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tabindex=\"-1\">In Vitro biological assays<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1882\"><a href=\"http:\/\/www.commedx.com\/en\/services\/pharmacokinetics-and-pharmacodynamics-studies\/\" class=\"elementor-sub-item menu-link\" tabindex=\"-1\">Pharmacokinetics and pharmacodynamics studies<\/a><\/li>\n<\/ul>\n<\/li>\n<li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-1886\"><a class=\"elementor-item menu-link\" tabindex=\"-1\">Customized early drug discovery services<\/a>\n<ul class=\"sub-menu elementor-nav-menu--dropdown\">\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1883\"><a href=\"http:\/\/www.commedx.com\/en\/services\/target-evaluation\/\" class=\"elementor-sub-item menu-link\" tabindex=\"-1\">Target evaluation<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1876\"><a href=\"http:\/\/www.commedx.com\/en\/services\/hit-discovery\/\" class=\"elementor-sub-item menu-link\" tabindex=\"-1\">Hit discovery<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1875\"><a href=\"http:\/\/www.commedx.com\/en\/services\/hit-and-lead-optimization\/\" class=\"elementor-sub-item menu-link\" tabindex=\"-1\">Hit and lead optimization<\/a><\/li>\n\t<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1878\"><a href=\"http:\/\/www.commedx.com\/en\/services\/integrated-one-stop-discovery\/\" class=\"elementor-sub-item menu-link\" tabindex=\"-1\">Integrated one-stop discovery<\/a><\/li>\n<\/ul>\n<\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-1881\"><a href=\"http:\/\/www.commedx.com\/en\/services\/other-services\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Other services<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-2ef7cc3b\" data-id=\"2ef7cc3b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-14d328f9\" data-id=\"14d328f9\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2d19a753 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2d19a753\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-71c1b6d2\" data-id=\"71c1b6d2\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1f216238 elementor-widget elementor-widget-heading\" data-id=\"1f216238\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Virtual screening<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f3e26ed elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"3f3e26ed\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-52eafbd6 elementor-widget elementor-widget-text-editor\" data-id=\"52eafbd6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div data-page-id=\"WjiBd8uhzoWCEVxoKGIc4hjBnkb\" data-docx-has-block-data=\"false\"><div class=\"ace-line ace-line old-record-id-doxcnVxTort3aKksXZ0yPCwcaBd\"><div data-page-id=\"WjiBd8uhzoWCEVxoKGIc4hjBnkb\" data-docx-has-block-data=\"false\"><div class=\"ace-line ace-line old-record-id-Q2fCdoGBto5ne3x2tdZc1kaJnod\">Virtual screening is an effective and cost-efficient approach for identifying lead compounds, leveraging algorithms to assess the potential biological activity of candidate molecules within a vast library, thereby significantly reducing the costs associated with experimental validation. This technique can be executed based on the three-dimensional structure of the target or known active ligands, and is primarily categorized into structure-based virtual screening (SBVS) and ligand-based virtual screening (LBVS):<\/div><ul class=\"list-bullet1\"><li class=\"ace-line ace-line old-record-id-R4sodXt3Lovh8sxx8slcREPnnRe\" data-list=\"bullet\"><div>Structure-based virtual screening (SBVS): This method employs the three-dimensional structural data of the target protein, using techniques like molecular docking to evaluate the binding capabilities of small molecules within the compound library to the target, aiming to identify candidates with potentially high binding energies. The effectiveness of this approach hinges on accurate modeling of the target protein structure and the use of appropriate scoring functions.<\/div><\/li><li class=\"ace-line ace-line old-record-id-QorXdTmG9oEIDlxf4aWcDzVCnXe\" data-list=\"bullet\"><div>Ligand-based virtual screening (LBVS): In the absence of target protein structural information, this approach utilizes the structural characteristics of known active ligands. Techniques such as artificial intelligence modeling and searches using three-dimensional pharmacophore models are employed to identify compounds in the library that either share structural similarities or pharmacophores with the reference ligands. Its strength lies in its independence from target structure information, though its accuracy is contingent upon the reliability of the reference ligands.<\/div><\/li><\/ul><div class=\"ace-line ace-line old-record-id-NsMkdMsa3oeqjHxkFgYclapUnte\">Virtual screening facilitates the rapid narrowing of candidate compounds and enhances the efficiency of lead compound discovery, increasingly becoming vital in modern drug development. With recent advancements in large-scale virtual screening, new opportunities have emerged for lead compound discovery. Theoretically, the potential chemical space for small molecule drug development is vast, estimated at 10^60, yet traditional virtual screening methods explore only a minuscule portion of this space. The breadth of chemical space that can be explored correlates directly with the screening scale; the more compounds screened, the broader the space, enhancing the likelihood of discovering high-affinity lead compounds. Recent research indicates that extensive screening significantly boosts the true positive rate of virtual screening.<\/div><\/div><\/div><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-195aade7 elementor-widget elementor-widget-heading\" data-id=\"195aade7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Large-Scale Virtual Screening Compared with Other Lead Compound Discovery Methods<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-246aa084 elementor-widget elementor-widget-image\" data-id=\"246aa084\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"443\" src=\"http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/output-1024x443.png\" class=\"attachment-large size-large wp-image-1775\" alt=\"\" srcset=\"http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/output-1024x443.png 1024w, http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/output-300x130.png 300w, http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/output-768x332.png 768w, http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/output-1536x665.png 1536w, http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/output-2048x886.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3ce46541 elementor-widget elementor-widget-text-editor\" data-id=\"3ce46541\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div data-page-id=\"WjiBd8uhzoWCEVxoKGIc4hjBnkb\" data-docx-has-block-data=\"false\"><div class=\"ace-line ace-line old-record-id-doxcn5W3ueluvxKoW5XklPst0Fe\"><div data-page-id=\"WjiBd8uhzoWCEVxoKGIc4hjBnkb\" data-docx-has-block-data=\"false\"><div class=\"ace-line ace-line old-record-id-U3G5dEbZNoGbGCx2IWgcCRrenKc\">ComMedX has a unique advantage in the field of structure-based large-scale virtual screening. Trained under internationally renowned experts, the company founders participated in high-level academic research, and engaged in collaborative R&amp;D with global pharmaceutical corporations. With a wealth of technical expertise, ComMedX offers industry-leading screening hit rates. We leverages performance-optimized advanced docking algorithms, active learning algorithms, and high-performance computing resources to achieve the high-throughput screening of over one billion compounds in just a few days. High-quality lead compounds are rapidly identified through an intelligent post-processing workflow, showcasing ComMedX&#8217;s innovative approach to drug discovery.<\/div><\/div><\/div><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6ac2bbb2 elementor-widget elementor-widget-heading\" data-id=\"6ac2bbb2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><span style=\"color: #ff610b;\" >Medx<\/span>Discovery: Combining Best Practices with Algorithm Optimization<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5e3aac88 elementor-widget elementor-widget-image\" data-id=\"5e3aac88\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"436\" src=\"http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/501-1024x436.png\" class=\"attachment-large size-large wp-image-1776\" alt=\"\" srcset=\"http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/501-1024x436.png 1024w, http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/501-300x128.png 300w, http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/501-768x327.png 768w, http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/501.png 1280w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-45c0cae6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"45c0cae6\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-149e16d4\" data-id=\"149e16d4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-15ea0aac elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"15ea0aac\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-2f0b4c84\" data-id=\"2f0b4c84\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3a471643 elementor-widget elementor-widget-heading\" data-id=\"3a471643\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">&nbsp Service offerings<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c751d86 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"2c751d86\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e31ba09 elementor-widget elementor-widget-text-editor\" data-id=\"2e31ba09\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div data-page-id=\"WjiBd8uhzoWCEVxoKGIc4hjBnkb\" data-docx-has-block-data=\"false\"><ul class=\"list-bullet1\"><li class=\"ace-line ace-line old-record-id-RhW0dIeS6oYjHdxM0VGcZTConUc\" data-list=\"bullet\"><div>Structure-based screening, ligand-based screening, and hybrid screening available based on customer needs<\/div><\/li><li class=\"ace-line ace-line old-record-id-NaNzdnq2aowvyAxmuBxcPPZZnYd\" data-list=\"bullet\"><div>Pre-research screening for targets includes binding pocket analysis, collection of known active compounds, binding mode and key interaction analysis, and pre-screening method effectiveness evaluation<\/div><\/li><li class=\"ace-line ace-line old-record-id-KnOcdQXPjoFIEjxpDoWcNv6Anxf\" data-list=\"bullet\"><div>Virtual compound libraries available in various sizes<\/div><\/li><li class=\"ace-line ace-line old-record-id-ZipGdxIl2oZXMUxKflZcNFV0nQh\" data-list=\"bullet\"><div>Multi-level filtering of screening results: docking scoring, ligand conformation energy filtering, re-scoring based on binding free energy, compound diversity filtering, pharmacokinetic rules filtering, protein-ligand interaction filtering<\/div><\/li><li class=\"ace-line ace-line old-record-id-Vzq7dVjkXoSZkXx7HgfcAPMNn4f\" data-list=\"bullet\"><div>ADMET pharmacokinetic filtering available<\/div><\/li><li class=\"ace-line ace-line old-record-id-AsHYdToNaotZZ1xjgkLcTmx8ngc\" data-list=\"bullet\"><div>Compound set recommendations manually selected by computational chemistry experts<\/div><\/li><li class=\"ace-line ace-line old-record-id-KlxndD9iuoOo45x3cPCcK8sznje\" data-list=\"bullet\"><div>Fragment screening and covalent screening available for specific targets<\/div><\/li><\/ul><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4d3391 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4d3391\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-3153165a\" data-id=\"3153165a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7177dac7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7177dac7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-10dec888\" data-id=\"10dec888\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-154b0a9b elementor-widget elementor-widget-heading\" data-id=\"154b0a9b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">&nbsp Why ComMedX<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27638fc2 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"27638fc2\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-241d1fed elementor-widget elementor-widget-text-editor\" data-id=\"241d1fed\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div data-page-id=\"WjiBd8uhzoWCEVxoKGIc4hjBnkb\" data-docx-has-block-data=\"false\"><ul class=\"list-bullet1\"><li class=\"ace-line ace-line old-record-id-VauCdXkCroIoFcxsfeQcMbIYn8G\" data-list=\"bullet\"><div>Deep expertise: Extensive experience and validated solutions from years of specialization.<\/div><\/li><li class=\"ace-line ace-line old-record-id-SyZ3d1nBsoHn6gx4iGdcpUgmn7W\" data-list=\"bullet\"><div>Professional workflows: Beyond automated calculations, strategies are customized and optimized with expert insights.<\/div><\/li><li class=\"ace-line ace-line old-record-id-DJgGd6OasoY6Wcx5cRVc0z3hnO5\" data-list=\"bullet\"><div>Tailored services: Screening solutions designed to meet specific client goals.<\/div><\/li><\/ul><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1bb412c2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1bb412c2\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-6d272240\" data-id=\"6d272240\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7dc49adf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7dc49adf\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-4b9f0b4f\" data-id=\"4b9f0b4f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f33aaf8 elementor-widget elementor-widget-template\" data-id=\"f33aaf8\" data-element_type=\"widget\" data-widget_type=\"template.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-template\">\n\t\t\t\t\t<div data-elementor-type=\"section\" data-elementor-id=\"1762\" class=\"elementor elementor-1762\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-219c3639 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"219c3639\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4e4d36b5\" data-id=\"4e4d36b5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5965b8f0 elementor-widget elementor-widget-heading\" data-id=\"5965b8f0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Business Inquiry<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-600dfed9 elementor-widget elementor-widget-text-editor\" data-id=\"600dfed9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>For more information, please send a message to\u00a0<span style=\"text-decoration: underline;\"><a href=\"mailto:contact@commedx.com\">contact@commedx.com <\/a><\/span><\/p><p>We will get in touch with you as soon as possible.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5e9df3fd elementor-widget elementor-widget-image\" data-id=\"5e9df3fd\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"428\" src=\"http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/p-1-1024x428.png\" class=\"attachment-large size-large wp-image-1572\" alt=\"\" srcset=\"http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/p-1-1024x428.png 1024w, http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/p-1-300x125.png 300w, http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/p-1-768x321.png 768w, http:\/\/www.commedx.com\/en\/wp-content\/uploads\/2024\/05\/p-1.png 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-249fb8a7\" data-id=\"249fb8a7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-51388497 elementor-button-align-stretch elementor-widget elementor-widget-form\" data-id=\"51388497\" data-element_type=\"widget\" data-settings=\"{&quot;step_next_label&quot;:&quot;Next&quot;,&quot;step_previous_label&quot;:&quot;Previous&quot;,&quot;button_width&quot;:&quot;100&quot;,&quot;step_type&quot;:&quot;number_text&quot;,&quot;step_icon_shape&quot;:&quot;circle&quot;}\" data-widget_type=\"form.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<form class=\"elementor-form\" method=\"post\" name=\"New Form\">\n\t\t\t<input type=\"hidden\" name=\"post_id\" value=\"1762\"\/>\n\t\t\t<input type=\"hidden\" name=\"form_id\" value=\"51388497\"\/>\n\t\t\t<input type=\"hidden\" name=\"referer_title\" value=\"\" \/>\n\n\t\t\t\n\t\t\t<div class=\"elementor-form-fields-wrapper elementor-labels-\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-type-text elementor-field-group elementor-column elementor-field-group-name elementor-col-100 elementor-field-required\">\n\t\t\t\t\t\t\t\t\t\t\t\t<label for=\"form-field-name\" class=\"elementor-field-label elementor-screen-only\">\n\t\t\t\t\t\t\t\tName\t\t\t\t\t\t\t<\/label>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<input size=\"1\" type=\"text\" name=\"form_fields[name]\" id=\"form-field-name\" class=\"elementor-field elementor-size-sm  elementor-field-textual\" placeholder=\"Name*\" required=\"required\" aria-required=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-type-number elementor-field-group elementor-column elementor-field-group-field_4fb8250 elementor-col-100 elementor-field-required\">\n\t\t\t\t\t\t\t\t\t\t\t\t<label for=\"form-field-field_4fb8250\" class=\"elementor-field-label elementor-screen-only\">\n\t\t\t\t\t\t\t\tPhone\t\t\t\t\t\t\t<\/label>\n\t\t\t\t\t\t\t\t\t<input type=\"number\" name=\"form_fields[field_4fb8250]\" id=\"form-field-field_4fb8250\" class=\"elementor-field elementor-size-sm  elementor-field-textual\" placeholder=\"Phone*\" required=\"required\" aria-required=\"true\" min=\"\" max=\"\" >\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-type-email elementor-field-group elementor-column elementor-field-group-email elementor-col-100 elementor-field-required\">\n\t\t\t\t\t\t\t\t\t\t\t\t<label for=\"form-field-email\" class=\"elementor-field-label elementor-screen-only\">\n\t\t\t\t\t\t\t\tEmail\t\t\t\t\t\t\t<\/label>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<input size=\"1\" type=\"email\" name=\"form_fields[email]\" id=\"form-field-email\" class=\"elementor-field elementor-size-sm  elementor-field-textual\" placeholder=\"Email*\" required=\"required\" aria-required=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-type-text elementor-field-group elementor-column elementor-field-group-field_9f6c164 elementor-col-100 elementor-field-required\">\n\t\t\t\t\t\t\t\t\t\t\t\t<label for=\"form-field-field_9f6c164\" class=\"elementor-field-label elementor-screen-only\">\n\t\t\t\t\t\t\t\tInstitution\t\t\t\t\t\t\t<\/label>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<input size=\"1\" type=\"text\" name=\"form_fields[field_9f6c164]\" id=\"form-field-field_9f6c164\" class=\"elementor-field elementor-size-sm  elementor-field-textual\" placeholder=\"Institution*\" required=\"required\" aria-required=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-type-textarea elementor-field-group elementor-column elementor-field-group-message elementor-col-100 elementor-field-required\">\n\t\t\t\t\t\t\t\t\t\t\t\t<label for=\"form-field-message\" class=\"elementor-field-label elementor-screen-only\">\n\t\t\t\t\t\t\t\tMessage\t\t\t\t\t\t\t<\/label>\n\t\t\t\t\t\t<textarea class=\"elementor-field-textual elementor-field  elementor-size-sm\" name=\"form_fields[message]\" id=\"form-field-message\" rows=\"4\" placeholder=\"Message*\" required=\"required\" aria-required=\"true\"><\/textarea>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"elementor-field-group elementor-column elementor-field-type-submit elementor-col-100 e-form__buttons\">\n\t\t\t\t\t<button type=\"submit\" class=\"elementor-button elementor-size-sm\">\n\t\t\t\t\t\t<span >\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\" elementor-button-icon\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Submit<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/button>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/form>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Drug Development Services Virtual screening Virtual screening is an effective and cost-efficient approach for identifying lead compounds, leveraging algorithms to assess the potential biological activity of candidate molecules within a vast library, thereby significantly reducing the costs associated with experimental validation. This technique can be executed based on the three-dimensional structure of the target or &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"http:\/\/www.commedx.com\/en\/services\/virtual-screening\/\"> <span class=\"screen-reader-text\">Virtual screening<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":18,"featured_media":0,"parent":1741,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/builder-fullwidth-std.php","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"enabled","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"_links":{"self":[{"href":"http:\/\/www.commedx.com\/en\/wp-json\/wp\/v2\/pages\/1746"}],"collection":[{"href":"http:\/\/www.commedx.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.commedx.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.commedx.com\/en\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"http:\/\/www.commedx.com\/en\/wp-json\/wp\/v2\/comments?post=1746"}],"version-history":[{"count":23,"href":"http:\/\/www.commedx.com\/en\/wp-json\/wp\/v2\/pages\/1746\/revisions"}],"predecessor-version":[{"id":1941,"href":"http:\/\/www.commedx.com\/en\/wp-json\/wp\/v2\/pages\/1746\/revisions\/1941"}],"up":[{"embeddable":true,"href":"http:\/\/www.commedx.com\/en\/wp-json\/wp\/v2\/pages\/1741"}],"wp:attachment":[{"href":"http:\/\/www.commedx.com\/en\/wp-json\/wp\/v2\/media?parent=1746"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}